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    Citation information in Europe Pubmed Central

    Citation information in Europe Pubmed Central

    Cited:

    90

    Scopus

    Summary. The basis for many of the symptoms and pathological changes found in patients with the acquired immunodeficiency syndrome (AIDS) remains poorly understood. We have used a quantitative polymerase chain reaction technique to investigate the extent to which direct infection with human immunodeficiency virus (HIV) produces the disease manifestations of AIDS. In five patients who died with AIDS-defining illnesses (Centers for Disease Control and Prevention class IV), we found variable, but in many cases extensive, infection by HIV at various sites, including brain, lung, colon, and liver. By contrast, in three HIV-positive subjects who died without HIV-related disease (CDC class II), we found no evidence of significant infection of any non-lymphoid organ. In both groups of patients there were high levels of infection in cells of the spleen, lymph nodes, and peripheral blood. Pathological examination of tissues from the AIDS patients revealed many abnormalities, of which some, such as giant-cell encephalitis in the brain, were specifically associated with the presence of high levels of HIV infection. These findings suggest that spread of HIV outside cells of the immune system is a late event in HIV infection and is extremely sensitive to the degree of immunosuppression in the patient. © 1994.

    Donaldson YK , Bell JE , Ironside JW , Brettle RP , Robertson JR , Busuttil A , Simmonds P . 1994. Redistribution of HIV outside the lymphoid system with onset of AIDS. Lancet , 343 (8894), pp. 383-385. | Show Abstract

    The basis for many of the symptoms and pathological changes found in patients with the acquired immunodeficiency syndrome (AIDS) remains poorly understood. We have used a quantitative polymerase chain reaction technique to investigate the extent to which direct infection with human immunodeficiency virus (HIV) produces the disease manifestations of AIDS. In five patients who died with AIDS-defining illnesses (Centers for Disease Control and Prevention class IV), we found variable, but in many cases extensive, infection by HIV at various sites, including brain, lung, colon, and liver. By contrast, in three HIV-positive subjects who died without HIV-related disease (CDC class II), we found no evidence of significant infection of any non-lymphoid organ. In both groups of patients there were high levels of infection in cells of the spleen, lymph nodes, and peripheral blood. Pathological examination of tissues from the AIDS patients revealed many abnormalities, of which some, such as giant-cell encephalitis in the brain, were specifically associated with the presence of high levels of HIV infection. These findings suggest that spread of HIV outside cells of the immune system is a late event in HIV infection and is extremely sensitive to the degree of immunosuppression in the patient.

    Citation information in Europe Pubmed Central

    To the Editor: Hepatitis C virus (HCV) is a major cause of chronic liver disease and of hepatocellular carcinoma. Several strains of HCV exist; distinct genotypes can be identified by sequence comparison of the viral genomes.1Recent evidence that the genotype of HCV may influence the clinical course of hepatitis C2and the response to interferon therapy for this disease3suggests that methods to identify the genotype may become clinically useful. Methods based on the polymerase chain reaction, however, are expensive, time-consuming, and limited to highly specialized laboratories. Serotype-specific immunodominant epitopes have recently been mapped to the NS4 region of… © 1994, Massachusetts Medical Society. All rights reserved.

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    My office serves a full range of real estate activities including a 5 person professional property management section focusing on "reasonable cost" professional property management. We also list and sell both new builders homes and resale homes throughout the San Antonio metroplex. Our listing fees for full service are low and we provide disclosed commission rebates to many of our buyers similar to the USAA concept.

    There is a saying in Texas " I was not born in Texas but got here as fast as I could". I am a little different, my last Air Force assignment to San Antonio and the Air Force Personnel Center (DPAA) was not my ideal dream location but after retiring and living here in this area for 12 years, San Antonio and the surrounding area is absolutely awesome. There is somewhere to go, something to see and something to do every day of the year from the wonderful festivals to Sea World, Fiesta Texas, dozens of golfing choices to simply tubing down the Guadalupe River - this area has it all.

    Whether you are a first time home buyer looking for your dream home, a seasoned investor searching for an REO/foreclosure or in need of selling a home, we have the knowledge and experience to guide you through the process. We specialize in Bexar, Guadalupe, and Comal County real estate covering San Antonio, and the surrounding counties including the cities of Schertz, Cibolo, Garden Ridge, Converse, Universal City, and New Braunfels.

    My office is on I-35 in Schertz less than 10 minutes from Randolph AFB and 15 minutes from Fort Sam/SAMC medical complex.

    Interested in a Real Estate career - see my additional web page for information - I started part-time for two years and absolutely love this profession that offers practically everything you could ask for from income to time for your other interests, family and so forth.

    It is our true hope that you will be so pleased with your experience, that you will turn to us for consultation on your future real estate needs and feel compelled to refer us to your friends, family and business associates.

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